Structure of PDB 7rfz Chain A Binding Site BS01

Receptor Information
>7rfz Chain A (length=425) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYF
Ligand information
>7rfz Chain B (length=19) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ARKRSHSPTKKLRYVKRRF
Receptor-Ligand Complex Structure
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PDB7rfz MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		S105 R106 P110 F138 W142 N146 S149 G150 T151 S152 Q181 W184 N188 G191 D192 W231 N235 R315 V321 T322 E354 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		S34 R35 P39 F67 W71 N75 S78 G79 T80 S81 Q110 W113 N117 G120 D121 W160 N164 R244 V250 T251 E283 W286 N290 E325 W328
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rfz, PDBe:7rfz, PDBj:7rfz
PDBsum7rfz
PubMed35338144
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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