Structure of PDB 7rfl Chain A Binding Site BS01

Receptor Information
>7rfl Chain A (length=552) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLE
VYDILYDLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAIS
ILKDSLTNKKVDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLE
KKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLES
LSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYI
DVFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDET
FYNKIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKC
WIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRR
ECKSGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADV
YSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKV
MKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSL
GI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7rfl Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.
Resolution2.38 Å
Binding residue
(original residue number in PDB)		H171 K172 K179 D192 K193 I349 G351 C352 D353 K378 K380 R425 Q438 W439 Y455 K456 A473
Binding residue
(residue number reindexed from 1)		H146 K147 K154 D167 K168 I324 G326 C327 D328 K353 K355 R400 Q413 W414 Y430 K431 A448
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7rfl, PDBe:7rfl, PDBj:7rfl
PDBsum7rfl
PubMed34523387
UniProtQ183J3

[Back to BioLiP]