Structure of PDB 7rfk Chain A Binding Site BS01

Receptor Information
>7rfk Chain A (length=568) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPY
PRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHI
LNYCIYGADIDEKAISILKDSLTNKKVVESDIKINLFCCDSLKKKWRYKF
DYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILK
QGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVS
SCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQ
RLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILS
KDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRI
LDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNE
NRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKIT
AKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGK
VEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7rfk Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H171 K172 K176 K179 D192 K193 I349 G351 D353 K378 K380 R425 Q438 W439 Y455 K456
Binding residue
(residue number reindexed from 1)		H162 K163 K167 K170 D183 K184 I340 G342 D344 K369 K371 R416 Q429 W430 Y446 K447
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7rfk, PDBe:7rfk, PDBj:7rfk
PDBsum7rfk
PubMed34523387
UniProtQ183J3

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