Structure of PDB 7r9z Chain A Binding Site BS01

Receptor Information
>7r9z Chain A (length=115) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFL
VPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEK
DEDGFLYMVYASQET
Ligand information
Ligand ID2LZ
InChIInChI=1S/C10H8FNO2/c11-7-1-2-9-8(4-7)6(5-12-9)3-10(13)14/h1-2,4-5,12H,3H2,(H,13,14)
InChIKeyGWLLOJBOPVNWNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC(=O)Cc1c[nH]c2ccc(F)cc12
OpenEye OEToolkits 2.0.7c1cc2c(cc1F)c(c[nH]2)CC(=O)O
ACDLabs 12.01O=C(O)Cc1c[NH]c2ccc(F)cc21
FormulaC10 H8 F N O2
Name(5-fluoro-1H-indol-3-yl)acetic acid
ChEMBLCHEMBL82870
DrugBank
ZINCZINC000000402910
PDB chain7r9z Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r9z A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Resolution1.72 Å
Binding residue
(original residue number in PDB)		F52 P55
Binding residue
(residue number reindexed from 1)		F49 P52
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008017 microtubule binding
GO:0008429 phosphatidylethanolamine binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000045 autophagosome assembly
GO:0000422 autophagy of mitochondrion
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0007254 JNK cascade
GO:0009267 cellular response to starvation
GO:0010040 response to iron(II) ion
GO:0010288 response to lead ion
GO:0016236 macroautophagy
GO:0031667 response to nutrient levels
GO:0034198 cellular response to amino acid starvation
GO:0038066 p38MAPK cascade
GO:0060395 SMAD protein signal transduction
GO:0070301 cellular response to hydrogen peroxide
GO:0071280 cellular response to copper ion
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0097352 autophagosome maturation
Cellular Component
GO:0000421 autophagosome membrane
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0044754 autolysosome
GO:0045202 synapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7r9z, PDBe:7r9z, PDBj:7r9z
PDBsum7r9z
PubMed34985287
UniProtQ9H492|MLP3A_HUMAN Microtubule-associated proteins 1A/1B light chain 3A (Gene Name=MAP1LC3A)

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