Structure of PDB 7r86 Chain A Binding Site BS01

Receptor Information

>7r86 Chain A (length=284) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISHVPAA
SFQSCRNLTILWLHSNALARIDAAAFTGLTLLEQLDLSDNAQLHVVDPTT
FHGLGHLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNNLQALPDNTFR
DLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDL
GRLMTLYLFANNLSMLPAEVLMPLRSLQYLRLNDNPWVCDCRARPLWAWL
QKFRGSSSEVPCNLPQRLADRDLKRLAASDLEGC

Ligand information

Ligand ID

FUC

InChI

InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1

InChIKey

SHZGCJCMOBCMKK-SXUWKVJYSA-N

SMILES

Software	SMILES
CACTVS 3.341	C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04	OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0	CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0	C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341	C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O

Formula

C6 H12 O5

Name

alpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose

PDB chain

7r86 Chain E Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7r86 RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Resolution	1.65 Å
Binding residue (original residue number in PDB)	H186 H210
Binding residue (residue number reindexed from 1)	H161 H185
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7r86, PDBe:7r86, PDBj:7r86
PDBsum	7r86
PubMed	34758294
UniProt	Q99PI8\|RTN4R_MOUSE Reticulon-4 receptor (Gene Name=Rtn4r)

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