Structure of PDB 7r70 Chain A Binding Site BS01

Receptor Information
>7r70 Chain A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQ
LEDGRTLSDYNIQKESTLHLVLRLRSGAVQNTIERFTFPHKYKKRRDTDE
KCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICRVDIETQL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7r70 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r70 Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.
Resolution2.499 Å
Binding residue
(original residue number in PDB)		C312 H314 C331 C334
Binding residue
(residue number reindexed from 1)		C120 H122 C139 C142
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7r70, PDBe:7r70, PDBj:7r70
PDBsum7r70
PubMed35246518
UniProtP0CG48|UBC_HUMAN Polyubiquitin-C (Gene Name=UBC);
Q6ZSG1|ARK2C_HUMAN E3 ubiquitin-protein ligase ARK2C (Gene Name=ARK2C)

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