Structure of PDB 7r5l Chain A Binding Site BS01

Receptor Information
>7r5l Chain A (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWI
FVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
Ligand information
Ligand IDI4S
InChIInChI=1S/C5H7N3O/c1-3-5(9)6-4(2)8-7-3/h1-2H3,(H,6,8,9)
InChIKeyWZMOVTWDPULYIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CC1=NNC(=NC1=O)C
CACTVS 3.385CC1=NC(=O)C(=NN1)C
FormulaC5 H7 N3 O
Name3,6-dimethyl-2~{H}-1,2,4-triazin-5-one
ChEMBLCHEMBL5179458
DrugBank
ZINCZINC000032190994
PDB chain7r5l Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7r5l Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		K416 S417 Y418 W432 C433 S434 W486 W491 D528
Binding residue
(residue number reindexed from 1)		K16 S17 Y18 W32 C33 S34 W86 W91 D128
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7r5l, PDBe:7r5l, PDBj:7r5l
PDBsum7r5l
PubMed36110386
UniProtQ9Y5A9|YTHD2_HUMAN YTH domain-containing family protein 2 (Gene Name=YTHDF2)

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