Structure of PDB 7r2t Chain A Binding Site BS01

Receptor Information

>7r2t Chain A (length=416) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALD
GRLQEGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQGSA
YGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAF
AYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGT
DEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVA
LAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVP
HLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADR
LYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDT
KGDYQKALLYLCGGDD

Ligand information

>7r2t Chain B (length=5) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SETSV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7r2t SYNJ2BP PDZ domain in complex with a synthetic Vangl2 peptide.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	L23 F25 N26 I27 V28 Q33 R46 H78 V82 F85 R86
Binding residue (residue number reindexed from 1)	L17 F19 N20 I21 V22 Q27 R40 H72 V76 F79 R80

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008092	cytoskeletal protein binding

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Molecular Function

External links

PDB	RCSB:7r2t, PDBe:7r2t, PDBj:7r2t
PDBsum	7r2t
PubMed	38142947
UniProt	P57105\|SYJ2B_HUMAN Synaptojanin-2-binding protein (Gene Name=SYNJ2BP)

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