Structure of PDB 7r0e Chain A Binding Site BS01

Receptor Information

>7r0e Chain A (length=709) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))

GMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFASICTHLEVCFMYS
DFHFIDERGESTIILKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLP
DLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMAT
KADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEI
TGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARI
EPFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDA
IKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENEEKIPRT
KNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRSLACWI
QSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATE
YIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKG
RSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQV
SRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDL
TKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEG
FSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWF
NSFLTHALR

Ligand information

>7r0e Chain R (length=18)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 7r0e Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
• Resolution: 2.51 Å
• Binding residue (original residue number in PDB): M477 H510 L511 R512 K572
• Binding residue (residue number reindexed from 1): M470 H503 L504 R505 K565

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:7r0e, PDBe:7r0e, PDBj:7r0e
• PDBsum: 7r0e
• PubMed: 36596301
• UniProt: M9TI86