Structure of PDB 7qwr Chain A Binding Site BS01

Receptor Information

>7qwr Chain A (length=244) Species: 9986 (Oryctolagus cuniculus)

GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHD
PGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNV
LPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLP
SGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRG
VAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGR

Ligand information

>7qwr Chain 5 (length=3493)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccgguucaacccggcggcggguccggccgugucggcgggucc
cccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcg
ccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcuc
ggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggc
cgagggagcgagacccgucgccgcgcucuccccccucgggggggccgggc
caccccucccacggcgcgaccgcucggggcggacuguccccagugcgccc
cgggcgggucgcgccgucgggcccgggggaggggccacgcggcgagcgca
cggggucggcggcgacgucggcuacccacccgacccgucuugaaacacgg
accaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgcc
guggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggauc
ccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccg
ccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagaug
gugaacuaugccugggcagggcgaagccagaggaaacucugguggagguc
cguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcg
aaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccuca
ggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugau
uagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaug
gguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccu
agugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacg
ccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaaggugu
ugguugauauagagccgaaucaacuagcccugaaaauggauggcgcugga
gcgucgggcccauacccggccgucgccggcagucgagaguggacgggagc
ccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgc
ugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcag
gugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggc
cgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucg
guccugagagaugggcgagcgccguuccgaagggacgggcgauggccucc
guugcccucggccgaucgaaagggagucggguucagauccccgaauccgg
aguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgau
cccggagaagccggcgggagccccggggagaguucucuuuucuuugugaa
gggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuu
ggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuug
aaaauccgggggagaggguguaaaucucgcgccgggccguacccauaucc
gcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagg
uaagggaagucggcaagccggauccguaacuucgggauaaggauuggcuc
uaagggcugggucggucgucggccggcgccuagcagccgacuuagaacug
gugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaag
gcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaug
ucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuau
gacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcau
gaauggaugaacgagauucccacugucccuaccuacuauccagcgaaacc
acagccaagggaacgggcuuggcggaaucagcggggaaagaagacccugu
ugagcuugacucuagucuggcacggugaagagacauguuuuuucacugac
ccggugaggcgggggggcgcucgcuucuggcgccaagcgcccggccgcgc
gccggccgggcgcgacccgcuccggggacagugccagguggggaguuuga
cuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcu
cagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuuga
ucuugauuuucaguacgaauacagaccgugaaagcggggccucacgaucc
uucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagg
gauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugau
ccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcgu
uggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgu
gagacagguuaguuuuacccuacugaugauguguuguugccaugguaauc
cugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuu
ggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaa
cgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcg
gagccucgguuggccucggauagccggucccccgcgggguccggugcgga
gugcccuucguccugggaaacggggcgcggccggagaggcggccgccccc
ucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucgu
agacgaccugcuucugggucgggguuucguacguagcagagcagcucccu
cgcugcgaucuauugaaagucagcccucgacacaaggguuugu

.........................<<<<<<.....<......>......
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>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>>..<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....<<<<<..((((((>>>>>..>>>..................
................<<....>>...............<<<......>>
>..................................<<<<<<<<..<<<..
....<<<<<<<<.....<<<<<<<<<<<...<<<....<<<<<.<....>
>>.>>>......>>>.>>>>>>>>>>>..........>>>.>>>>>..<<
<<<<<..<<<<<<<<<<.<<<..........<<<<.<<<<......<<<<
<..>>>>>.......>>>>.>>>>............>>>...>>>>>>>>
>>....................<<<<<..<<<<<<<.>>>>>>>.<<.<<
<.<<<<..<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>
>>>>>.>>>>>>>>>>>.>>....>.>>>...>>>..>>.....>>>>>.
......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>>
<<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>...
..>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<
<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<
......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<
<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>
>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<..
.....>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....
>>>.><<<<<<<<<<............<<<<<<<<<...<<<....<<<.
.<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>
>>>>>...<<<<<<<<<..<...>.>>>>>>>>>...>>...>>>>>>>.
>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<
<<<<<<<............>>>>>>>>>>>>..........))).>>...
>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].)))...
...........................>>>>>>>>>....>>>>>>...<
<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>
........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<
<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<
<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>
>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<
....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<
<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<
<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>
.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.....
....>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<
......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<
<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<
<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>.
...........<<<<<<<<<..<<<.........>>>..<<<<<<<....
<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<
<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<......
.>>>>>.........<...........<<<<<.......>>>>>.....>
.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>
....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.
<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<
<<<<.....<<<<..<<...>>..............<<<<<<<<<<<...
..>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<
<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<.
..<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...
<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))......<<
<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>
.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>
.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.
<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<
<<<<.................>>>>>.><<<<....<<<<....<<.<<<
<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...
........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<
<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>.....
...>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>
...>>>>..>>..............>>>..>>>>>>>>.<<<<<.<....
.........>....<<.<<<<<<<.<<.....<<<<....<<<<<.....
.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qwr Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): G2 R3 V4 G7 Q8 R9 K10 G11 V15 A18 H19 V20 K21 H22 R23 K24 G25 F34 R37 H38 G39 Y40 I44 H50 P52 R54 Y67 R68 F69 K70 R72 G85 F87 Y89 A94 Q95 E118 G121 K125 L126 A127 R128 A129 S130 N132 L150 P151 S152 S154 K156 G172 G173 R174 K177 I179 L180 K181 A182 G183 H187 K188 R193 N194 W196 R198 V199 R200 G201 V202 A203 M204 N205 P206 V207 E208 H209 G214 N215 Q217 H218 G220 K221 P222 S223 T224 I225 R226 R227 P230 A231 G232 R233 V235 G236 L237 I238 A239 A240 R241 R242 T243 G244 R245
• Binding residue (residue number reindexed from 1): G1 R2 V3 G6 Q7 R8 K9 G10 V14 A17 H18 V19 K20 H21 R22 K23 G24 F33 R36 H37 G38 Y39 I43 H49 P51 R53 Y66 R67 F68 K69 R71 G84 F86 Y88 A93 Q94 E117 G120 K124 L125 A126 R127 A128 S129 N131 L149 P150 S151 S153 K155 G171 G172 R173 K176 I178 L179 K180 A181 G182 H186 K187 R192 N193 W195 R197 V198 R199 G200 V201 A202 M203 N204 P205 V206 E207 H208 G213 N214 Q216 H217 G219 K220 P221 S222 T223 I224 R225 R226 P229 A230 G231 R232 V234 G235 L236 I237 A238 A239 R240 R241 T242 G243 R244

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:7qwr, PDBe:7qwr, PDBj:7qwr
• PDBsum: 7qwr
• PubMed: 35201867
• UniProt: A0A5F9D5B2