Structure of PDB 7qot Chain A Binding Site BS01

Receptor Information
>7qot Chain A (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSED
PTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLD
MKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKH
TQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVM
APDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRI
KKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQK
LCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGY
TLRLC
Ligand information
>7qot Chain C (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DDDWIPDIQIDPNGLSFNPISDFPD
Receptor-Ligand Complex Structure
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PDB7qot Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
Resolution3.24 Å
Binding residue
(original residue number in PDB)		K103 I105 N106 H127 F138 H143 I146 L148 L163 N196 I197 W228 Q233 L238 S242 E243 K253 S254
Binding residue
(residue number reindexed from 1)		K102 I104 N105 H126 F137 H142 I145 L147 L162 N195 I196 W227 Q232 L237 S241 E242 K252 S253
Enzymatic activity
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Gene Ontology
Cellular Component
GO:0005576 extracellular region

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Biological Process
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Cellular Component
External links
PDB RCSB:7qot, PDBe:7qot, PDBj:7qot
PDBsum7qot
PubMed30801944
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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