Structure of PDB 7qnz Chain A Binding Site BS01

Receptor Information
>7qnz Chain A (length=640) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDI
ARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLA
ALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVP
DLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEA
AFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLP
SVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFD
LIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFL
EQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVV
IGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQS
LKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGL
VDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB7qnz Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing.
Resolution4.58 Å
Binding residue
(original residue number in PDB)		E346 G348 G350 G571 Q572 S588 R589 E592 F635 F872
Binding residue
(residue number reindexed from 1)		E85 G87 G89 G310 Q311 S327 R328 E331 F374 F611
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0009653 anatomical structure morphogenesis
GO:0033151 V(D)J recombination
GO:0051301 cell division
GO:0071897 DNA biosynthetic process
GO:1903461 Okazaki fragment processing involved in mitotic DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qnz, PDBe:7qnz, PDBj:7qnz
PDBsum7qnz
PubMed36539424
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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