Structure of PDB 7qju Chain A Binding Site BS01

Receptor Information
>7qju Chain A (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP
GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV
GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS
IWRWDRL
Ligand information
>7qju Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SMFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qju Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 E107 D109 V112 Y154 S159 H160 P161 I178 R201 L246 L315 G316 D317 L318 F372 W373 Q374 L391 E392 E394 R420
Binding residue
(residue number reindexed from 1)		W27 H28 S29 E31 D33 V36 Y78 S83 H84 P85 I102 R125 L170 L232 G233 D234 L235 F289 W290 Q291 L308 E309 E311 R337
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7qju, PDBe:7qju, PDBj:7qju
PDBsum7qju
PubMed35352560
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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