Structure of PDB 7qfb Chain A Binding Site BS01

Receptor Information
>7qfb Chain A (length=290) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHMGSLNLDSIIGRLLEVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
KIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPD
KDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAK
RQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
Ligand information
>7qfb Chain B (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KKRVVFADSKGLSLTAIHVFSD
Receptor-Ligand Complex Structure
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PDB7qfb Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		R74 Y78 D166 E167 K168 D242 Y255 F257 R261 E287 L289 M290 C291 S292 F293 Q294 I295 L296 K297 P298 A299
Binding residue
(residue number reindexed from 1)		R64 Y68 D156 E157 K158 D232 Y245 F247 R251 E277 L279 M280 C281 S282 F283 Q284 I285 L286 K287 P288 A289
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7qfb, PDBe:7qfb, PDBj:7qfb
PDBsum7qfb
PubMed36261419
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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