Structure of PDB 7qdy Chain A Binding Site BS01

Receptor Information
>7qdy Chain A (length=1169) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MMETERLVLPPPDPLDLPLRAVELGCTGHWELLNLPGAPESSLPHGLPPC
APDLQQEAEQLFLSSPAWLPLHGVEHSARKWQRKTDPWSLLAVLGAPVPS
DLQAQRHPTTGQILGYKEVLLENTNLSATTSLSLRRPPGPASQSLWGNPT
QYPFWPGGMDEPTITDLNTREEAEEEIDFEKDLLTIPPGFKKGMDFAPKD
CAPGLLLARASSLEDLVLKEQWAIPVDATSPVGDFYRLIPQPAFQWAFEP
DVFQKQAILHLERHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSP
IKALSNQKFRDFRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGS
DVIRDLEWVIFDEVHYINDVERGVVWEEVLIMLPDHVSIILLSATVPNAL
EFADWIGRLKRRQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLLDSRG
AFHTKGYYAAVEAKKERMGPAQDRGVYLSLLASLRTRAQLPVVVFTFSRG
RCDEQASGLTSLDLTTSSEKSEIHLFLQRCLARLRGSDRQLPQVLHMSEL
LNRGLGVHHSGILPILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTVV
FDSMRKHDGSTFRDLLPGEYVQMAGRAGRRGLDPTGTVILLCKGRVPEMA
DLHRMMMGKPSQLQSQFRLTYTMILNLLRVDALRVEDMMKRSFSEFPSRK
DSKAHEQALAELTKRLGALEEPDMTGQLVDLPEYYSWGEELTETQHMIQR
RIMESVNGLKSLSAGRVVVVKNQEHHNALGVILQVSSNSTSRVFTTLVLC
DKPLSQDPQDRGPATAEVPYPDDLVGFKLFLPEGPCDHTVVKLQPGDMAA
ITTKVLRVNGEKILEDFSKRQQPKFKKDPPLAAVTTAVQELLRLAQAHPA
GPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQGAQCVHSPRFPAQYLKL
RERMQIQKEMERLRFLLSDQSLLLLPEYHQRVEVLRTLGYVDEAGTVKLA
GRVACAMSSHELLLTELMFDNALSTLRPEEIAALLSGLVCQSPGDAGDQL
PNTLKQGIERVRAVAKRIGEVQVACGLNQTVEEFVGELNFGLVEVVYEWA
RGMPFSELAGLSGTPEGLVVRCIQRLAEMCRSLRGAARLVGEPVLGAKME
TAATLLRRDIVFAASLYTQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qdy The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K363 G385 E401 R433 F574 S575 R576 S637 E663 T664 M667 H684 D685 S1085 Q1118 R1198
Binding residue
(residue number reindexed from 1)		K302 G324 E340 R372 F497 S498 R499 S560 E586 T587 M590 H607 D608 S1008 Q1041 R1121
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0034458 3'-5' RNA helicase activity
Biological Process
GO:0006401 RNA catabolic process
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
GO:0072344 rescue of stalled ribosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0055087 Ski complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qdy, PDBe:7qdy, PDBj:7qdy
PDBsum7qdy
PubMed35120588
UniProtQ15477|SKI2_HUMAN Superkiller complex protein 2 (Gene Name=SKIC2)

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