Structure of PDB 7qc8 Chain A Binding Site BS01

Receptor Information

>7qc8 Chain A (length=250) Species: 243274 (Thermotoga maritima MSB8)

SLAKRIIAALEVKDGRVVKGTNFENLRDSGDPAELGKFYSEIGIDELVFH
DHTASVEKRKTMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKV
SINTAAVENPSLITQIAQTFGSQAVVVAIDAKRVDGEFMVFTYSGKKNTG
ILLRDWVVEVEKRGAGEILLTSIDRDGTKSGYDTEMIRFVRPLTTLPIIA
SGGAGKMEHFLEAFLAGADAALAASVFHFREIDVRELKEYLKKHGVNVRL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7qc8 Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qc8 An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): E11 H50 H52
• Binding residue (residue number reindexed from 1): E11 H50 H52
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.3.2.10: imidazole glycerol-phosphate synthase.

Gene Ontology

Molecular Function

• GO:0000107 imidazoleglycerol-phosphate synthase activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7qc8, PDBe:7qc8, PDBj:7qc8
• PDBsum: 7qc8
• PubMed: 35841720
• UniProt: Q9X0C6|HIS6_THEMA Imidazole glycerol phosphate synthase subunit HisF (Gene Name=hisF)