BioLiP

>7q3y Chain A (length=1201) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAEN
ARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRTLGS
ANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASS
RSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRS
WYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPA
HLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEF
FTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTR
VTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVS
TPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVF
SGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIR
YFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSR
PWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWH
PPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNIT
TETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLER
AALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRK
YEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMY
ETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHL
LGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFT
SLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVN
LEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTP
KHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDG
SITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYF
VSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPW
PEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPN
S

Software

SMILES

CACTVS 3.341

[Zn++]

ACDLabs 10.04
OpenEye OEToolkits 1.5.0

[Zn+2]

Molecular Function

GO:0004175

endopeptidase activity

GO:0004180

carboxypeptidase activity

GO:0004222

metalloendopeptidase activity

GO:0005516

calmodulin binding

GO:0008233

peptidase activity

GO:0008237

metallopeptidase activity

GO:0008238

exopeptidase activity

GO:0008240

tripeptidyl-peptidase activity

GO:0008241

peptidyl-dipeptidase activity

GO:0008270

zinc ion binding

GO:0031404

chloride ion binding

GO:0031434

mitogen-activated protein kinase kinase binding

GO:0031711

bradykinin receptor binding

GO:0046872

metal ion binding

GO:0051019

mitogen-activated protein kinase binding

GO:0070573

metallodipeptidase activity

GO:1901363

heterocyclic compound binding

	Biological Process
GO:0001666	response to hypoxia
GO:0001822	kidney development
GO:0001974	blood vessel remodeling
GO:0002003	angiotensin maturation
GO:0002019	regulation of renal output by angiotensin
GO:0002446	neutrophil mediated immunity
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0007283	spermatogenesis
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0008584	male gonad development
GO:0009410	response to xenobiotic stimulus
GO:0009792	embryo development ending in birth or egg hatching
GO:0010608	post-transcriptional regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010814	substance P catabolic process
GO:0010815	bradykinin catabolic process
GO:0014910	regulation of smooth muscle cell migration
GO:0019229	regulation of vasoconstriction
GO:0030324	lung development
GO:0031100	animal organ regeneration
GO:0031667	response to nutrient levels
GO:0032496	response to lipopolysaccharide
GO:0032943	mononuclear cell proliferation
GO:0034616	response to laminar fluid shear stress
GO:0038166	angiotensin-activated signaling pathway
GO:0042310	vasoconstriction
GO:0042445	hormone metabolic process
GO:0042447	hormone catabolic process
GO:0042755	eating behavior
GO:0043065	positive regulation of apoptotic process
GO:0043171	peptide catabolic process
GO:0045777	positive regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0046325	negative regulation of D-glucose import
GO:0048167	regulation of synaptic plasticity
GO:0048286	lung alveolus development
GO:0050435	amyloid-beta metabolic process
GO:0050482	arachidonate secretion
GO:0050769	positive regulation of neurogenesis
GO:0060047	heart contraction
GO:0060177	regulation of angiotensin metabolic process
GO:0060218	hematopoietic stem cell differentiation
GO:0060978	angiogenesis involved in coronary vascular morphogenesis
GO:0071333	cellular response to glucose stimulus
GO:0071548	response to dexamethasone
GO:0071838	cell proliferation in bone marrow
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090281	negative regulation of calcium ion import
GO:0097066	response to thyroid hormone
GO:0097746	blood vessel diameter maintenance
GO:1902033	regulation of hematopoietic stem cell proliferation
GO:1903597	negative regulation of gap junction assembly
GO:1904045	cellular response to aldosterone
GO:2000170	positive regulation of peptidyl-cysteine S-nitrosylation

Biological Process

GO:0001666

response to hypoxia

GO:0001822

kidney development

GO:0001974

blood vessel remodeling

GO:0002003

angiotensin maturation

GO:0002019

regulation of renal output by angiotensin

GO:0002446

neutrophil mediated immunity

GO:0002474

antigen processing and presentation of peptide antigen via MHC class I

GO:0003081

regulation of systemic arterial blood pressure by renin-angiotensin

GO:0003084

positive regulation of systemic arterial blood pressure

GO:0006508

proteolysis

GO:0006518

peptide metabolic process

GO:0007283

spermatogenesis

GO:0007565

female pregnancy

GO:0008217

regulation of blood pressure

GO:0008584

male gonad development

GO:0009410

response to xenobiotic stimulus

GO:0009792

embryo development ending in birth or egg hatching

GO:0010608

post-transcriptional regulation of gene expression

GO:0010629

negative regulation of gene expression

GO:0010814

substance P catabolic process

GO:0010815

bradykinin catabolic process

GO:0014910

regulation of smooth muscle cell migration

GO:0019229

regulation of vasoconstriction

GO:0030324

lung development

GO:0031100

animal organ regeneration

GO:0031667

response to nutrient levels

GO:0032496

response to lipopolysaccharide

GO:0032943

mononuclear cell proliferation

GO:0034616

response to laminar fluid shear stress

GO:0038166

angiotensin-activated signaling pathway

GO:0042310

vasoconstriction

GO:0042445

hormone metabolic process

GO:0042447

hormone catabolic process

GO:0042755

eating behavior

GO:0043065

positive regulation of apoptotic process

GO:0043171

peptide catabolic process

GO:0045777

positive regulation of blood pressure

GO:0045907

positive regulation of vasoconstriction

GO:0046325

negative regulation of D-glucose import

GO:0048167

regulation of synaptic plasticity

GO:0048286

lung alveolus development

GO:0050435

amyloid-beta metabolic process

GO:0050482

arachidonate secretion

GO:0050769

positive regulation of neurogenesis

GO:0060047

heart contraction

GO:0060177

regulation of angiotensin metabolic process

GO:0060218

hematopoietic stem cell differentiation

GO:0060978

angiogenesis involved in coronary vascular morphogenesis

GO:0071333

cellular response to glucose stimulus

GO:0071548

response to dexamethasone

GO:0071838

cell proliferation in bone marrow

GO:0086091

regulation of heart rate by cardiac conduction

GO:0090281

negative regulation of calcium ion import

GO:0097066

response to thyroid hormone

GO:0097746

blood vessel diameter maintenance

GO:1902033

regulation of hematopoietic stem cell proliferation

GO:1903597

negative regulation of gap junction assembly

GO:1904045

cellular response to aldosterone

GO:2000170

positive regulation of peptidyl-cysteine S-nitrosylation

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0031526	brush border membrane
GO:0031982	vesicle
GO:0070062	extracellular exosome
GO:0097225	sperm midpiece

Cellular Component

extracellular region

extracellular space

cytoplasm

lysosome

endosome