Structure of PDB 7prw Chain A Binding Site BS01

Receptor Information
>7prw Chain A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCI
IDKIRRKNCPACRYRKCLQAGMNLPQLTPTLVSLLEVIEPEVLYAGYDSS
VPDSTWRIMTTLNMLGGRQMIAAVKWAKAIPGFRNLHLDDQMTLLQYSWM
SLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPDMYDQCKHMLYVSS
ELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAI
VKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPE
MLAEIITNQIPKYSNGNIKKLLFHQK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7prw Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Resolution2.502 Å
Binding residue
(original residue number in PDB)		G439 S440 R447 R470 R477
Binding residue
(residue number reindexed from 1)		G25 S26 R33 R56 R63
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7prw, PDBe:7prw, PDBj:7prw
PDBsum7prw
PubMed36747092
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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