Structure of PDB 7ppn Chain A Binding Site BS01

Receptor Information
>7ppn Chain A (length=279) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHD
GDPNEPVSDYINANIIMPEFGSSGKKSYIATQGCLQNTVNDFWRMVFQEN
SRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLR
ELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESI
MDAGPVVVHSSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS
QRSGMVQTEAQYRFIYMAVQHYIETLQRR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ppn Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y38 K39 N40 S213 S214 A215 I217 G218 R219 Q260
Binding residue
(residue number reindexed from 1)		Y35 K36 N37 S210 S211 A212 I214 G215 R216 Q257
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ppn, PDBe:7ppn, PDBj:7ppn
PDBsum7ppn
PubMed36114179
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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