Structure of PDB 7ppm Chain A Binding Site BS01

Receptor Information
>7ppm Chain A (length=277) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDG
DPNEPVSDYINANIIMPEFGSSGKKSYIATQGCLQNTVNDFWRMVFQENS
RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRE
LKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM
DAGPVVVHSSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQ
RSGMVQTEAQYRFIYMAVQHYIETLQR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ppm Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Resolution1.48 Å
Binding residue
(original residue number in PDB)		N36 R37 Y38 K39 N40 S213 S214 A215 I217 G218 R219 Q260
Binding residue
(residue number reindexed from 1)		N32 R33 Y34 K35 N36 S209 S210 A211 I213 G214 R215 Q256
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ppm, PDBe:7ppm, PDBj:7ppm
PDBsum7ppm
PubMed36114179
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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