Structure of PDB 7pmy Chain A Binding Site BS01

Receptor Information
>7pmy Chain A (length=657) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFS
SLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQV
VHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLS
INAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSK
IYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPK
QLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQ
PDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLA
FAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLI
ESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLV
IREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVG
EDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTN
QGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSS
MKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLLLVICLIFS
IMGYYYV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pmy Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		Y61 K161 Y188 N192 W313 E622
Binding residue
(residue number reindexed from 1)		Y21 K121 Y148 N152 W273 E582
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015293 symporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0035673 oligopeptide transmembrane transporter activity
GO:0042937 tripeptide transmembrane transporter activity
GO:0071916 dipeptide transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0015835 peptidoglycan transport
GO:0042908 xenobiotic transport
GO:0042938 dipeptide transport
GO:0045087 innate immune response
GO:0055085 transmembrane transport
GO:0070293 renal absorption
GO:0070424 regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0140206 dipeptide import across plasma membrane
GO:0140207 tripeptide import across plasma membrane
GO:0140367 antibacterial innate immune response
GO:0150104 transport across blood-brain barrier
GO:1902600 proton transmembrane transport
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pmy, PDBe:7pmy, PDBj:7pmy
PDBsum7pmy
PubMed34730990
UniProtQ16348|S15A2_HUMAN Solute carrier family 15 member 2 (Gene Name=SLC15A2)

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