Structure of PDB 7pmx Chain A Binding Site BS01

Receptor Information
>7pmx Chain A (length=657) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDNLSTAIYHTFVAL
CYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDSLPV
HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAI
NAGSLLSTIITPMLRVQQQACYPLAFGVPAALMAVALIVFVLGSGMYKKF
KPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQ
IKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQ
TVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAA
IVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNA
FMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDG
LNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIK
GFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISA
NTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTV
AVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPA
EIEAQFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pmx Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R27 Y31 Y167 N171 E595
Binding residue
(residue number reindexed from 1)		R16 Y20 Y147 N151 E569
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015333 peptide:proton symporter activity
GO:0022857 transmembrane transporter activity
GO:0035673 oligopeptide transmembrane transporter activity
GO:0042937 tripeptide transmembrane transporter activity
GO:0071916 dipeptide transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0055085 transmembrane transport
GO:0140206 dipeptide import across plasma membrane
GO:0140207 tripeptide import across plasma membrane
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pmx, PDBe:7pmx, PDBj:7pmx
PDBsum7pmx
PubMed34730990
UniProtP46059|S15A1_HUMAN Solute carrier family 15 member 1 (Gene Name=SLC15A1)

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