Structure of PDB 7pmc Chain A Binding Site BS01

Receptor Information
>7pmc Chain A (length=742) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELYTKYARVWIPDPEEVWKSAELLKDYKPKVLQLRLKDLEYCLDPLPPLR
NPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPY
EQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSG
ESGAGKTVSAKYAMRYFATVSEANVEEKVLASNPIMESIGNAKTTRNDNS
SRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCA
SAALPEFKTLRLGNANYFHYTKQGGSPVIDGIDDAKEMVNTRQACTLLGI
SDSYQMGIFRILAGILHLGNVEFASRDSDSCAIPPKHDPLTIFCDLMGVD
YEEMAHWLCHRKLATATETYIKPISKLHAINARDALAKHIYANLFNWIVD
HVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNM
HVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAKMGVLDLLDEECKMPK
GSDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIKHFADKVEYQCEGFLEK
NKDTVYEEQIKVLKSSKKFKLLPELFQDSKEHKKTVGHQFRNSLHLLMET
LNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPS
RWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIF
FRAGQVAYLEKIRADKLRAACIRIQKTIRGWLMRKKYMRMRR
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7pmc Chain A Residue 1902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pmc High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		N111 Y113 Y119 G166 A167 G168 K169 T170 V171
Binding residue
(residue number reindexed from 1)		N98 Y100 Y106 G153 A154 G155 K156 T157 V158
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7pmc, PDBe:7pmc, PDBj:7pmc
PDBsum7pmc
PubMed34812732
UniProtQ02440|MYO5A_CHICK Unconventional myosin-Va (Gene Name=MYO5A)

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