Structure of PDB 7pm5 Chain A Binding Site BS01

Receptor Information
>7pm5 Chain A (length=746) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELYTKYARVWIPDPEEVWKSAELLKDYKPKVLQLRLEEGKDLEYCLDPLP
PLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAI
NPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSII
VSGESGAGKTVSAKYAMRYFATVSGSANVEEKVLASNPIMESIGNAKTTR
NDNSSRFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFY
QLCASAALPEFKTLRLGNANYFHYTKQGGSPVIDGIDDAKEMVNTRQACT
LLGISDSYQMGIFRILAGILHLGNVEFASRDSDSCAIPPKHDPLTIFCDL
MGVDYEEMAHWLCHRKLATATETYIKPISKLHAINARDALAKHIYANLFN
WIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQ
QFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAKMGVLDLLDEEC
KMPKGSDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIKHFADKVEYQCEG
FLEKNKDTVYEEQIKVLKSSKKFKLLPELFQDSKEHKKTVGHQFRNSLHL
LMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAA
GFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDKYQFGK
TKIFFRAGQVAYLEKIRADKLRAACIRIQKTIRGWLMRKKYMRMRR
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7pm5 Chain A Residue 1902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pm5 High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		N111 P112 Y113 E114 Y119 G166 G168 K169 T170 V171
Binding residue
(residue number reindexed from 1)		N101 P102 Y103 E104 Y109 G156 G158 K159 T160 V161
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7pm5, PDBe:7pm5, PDBj:7pm5
PDBsum7pm5
PubMed34812732
UniProtQ02440|MYO5A_CHICK Unconventional myosin-Va (Gene Name=MYO5A)

[Back to BioLiP]