Structure of PDB 7p8q Chain A Binding Site BS01

Receptor Information
>7p8q Chain A (length=275) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSYRHSFHAGNHADVLKHTVQSLIIESLKEKDKPFLYLDTHAGAGRYQLG
SETGEYLEGIARIWQQDDLPAELEAYINVVKHFNRSGQLRYYPGSPLIAR
QLLREQDSLQLTELHPSDYPLLRSEFQKDSRARVEKADGFQQLKAKLPPV
SRRGLILIDPPYEMKTDYQAVVSGIAEGYKRFATGTYALWYPVVLRQQIK
RMIHDLEATGIRKILQIELAVLPDSDRRGMTASGMIVINPPWKLEQQMNN
VLPWLHSKLVPAGTGHATVSWIVPE
Ligand information
Receptor-Ligand Complex Structure
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PDB7p8q Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase.
Resolution2.289 Å
Binding residue
(original residue number in PDB)		H9 N12 K18 E60 Y167 E168 Y173 W195 V199
Binding residue
(residue number reindexed from 1)		H8 N11 K17 E55 Y162 E163 Y168 W190 V194
Enzymatic activity
Enzyme Commision number 2.1.1.266: 23S rRNA (adenine(2030)-N(6))-methyltransferase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0008988 rRNA (adenine-N6-)-methyltransferase activity
GO:0036307 23S rRNA (adenine(2030)-N(6))-methyltransferase activity
Biological Process
GO:0006364 rRNA processing
GO:0015976 carbon utilization
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p8q, PDBe:7p8q, PDBj:7p8q
PDBsum7p8q
PubMed35580049
UniProtP37634|RLMJ_ECOLI Ribosomal RNA large subunit methyltransferase J (Gene Name=rlmJ)

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