Structure of PDB 7p8l Chain A Binding Site BS01

Receptor Information
>7p8l Chain A (length=242) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMIARIIGEIGIEGARFIEENIDEQFKALRYLSKGIDSETFVKLVIAN
SLVSYQLTGKGEQWWWEFAKYFYGRDVKSIYLAYKEFLPNSRFNRRLIPQ
KLSRIRRVETFLSTLTEERIEEYYGDMSSLWGSIARALGVDKESQTVVFS
VKMFGYAARIVLSTFNPYPMEIPIPEDSRIVKLTKKLTNEKPRKFWMKIA
RESGVPPLHIDSILWPLLGGASIDSAPPELRDKLAELIKIIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7p8l Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing.
Resolution1.25 Å
Binding residue
(original residue number in PDB)		Q24 Y52 Q53 L54 T55 G56 K57 G58 R93 R101 R104 Q142 T143 F146 P172 D174 R176 D208 W212
Binding residue
(residue number reindexed from 1)		Q27 Y55 Q56 L57 T58 G59 K60 G61 R96 R104 R107 Q145 T146 F149 P175 D177 R179 D211 W215
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0000702 oxidized base lesion DNA N-glycosylase activity
GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7p8l, PDBe:7p8l, PDBj:7p8l
PDBsum7p8l
PubMed36300625
UniProtQ9UZY0|AGOG_PYRAB N-glycosylase/DNA lyase (Gene Name=PYRAB10170)

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