Structure of PDB 7ovs Chain A Binding Site BS01

Receptor Information
>7ovs Chain A (length=382) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKLSLIKVVNGCRLGKIQNLGKAGDCTVDIPGCLLYTRTGSAPHLTHQTL
RNIHGVPGIAQLTLSSLAEHHEVLAEYKKGVGSFIGMPESLFYCSLHDPV
TPGPAGYVTSKSVSVWGFGGRVEMTVSKFMAIQEALQPDWFQCLSDGEAS
CAETTSIKRARKSVDRSLLFLDSCLRLQEESEVLQKSVIIGVIEGGDVME
ERLRSARETAKRPVGGFLLDGFQGDPAVTETRLHLLSSVTAELPEDKPRL
ICGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFTFDCQLEMTSFE
INLKEKKYQEDFDPLVRGCSCYCCKNHTRAYIHHLLMTNELLAGVLLMMH
NFEHYFGFFCSIREALKNDTLAQLKELICRQM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ovs Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ovs Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C351 C353 C356 H382
Binding residue
(residue number reindexed from 1)		C319 C321 C324 H350
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.29: tRNA-guanosine(34) preQ1 transglycosylase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016763 pentosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ovs, PDBe:7ovs, PDBj:7ovs
PDBsum7ovs
PubMed35815944
UniProtB8ZXI1|QTRT2_MOUSE Queuine tRNA-ribosyltransferase accessory subunit 2 (Gene Name=Qtrt2)

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