Structure of PDB 7oro Chain A Binding Site BS01

Receptor Information
>7oro Chain A (length=2008) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKHVSKPKILDFDDANMYLASLTMMEQSK
KILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFS
TLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSAKATVVYSIIVLHKE
EENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFLTTCLL
FKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAISSNVK
DYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDIT
QKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVMVDLA
KTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSRHNHL
RNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKEYEMLRNAMPNYTD
YISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKFYFTFFNKGQKTS
KDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEPGDGKLKVLEQKS
EQEIRFLVETTRQKNREIDEAIEIEKLSLGKAKGLKMEINADMSKWSAQD
VFYKYFWLIALDPILYPQEKERILYFMCNYMDKELILPDELLFNLLDQKV
AYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCAMSVYKEILK
EAITLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFAMKEFERACL
TFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTSVGDCAYIGP
YEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNMLPGQSNDPI
DYFPAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIKLLSKYTPVM
QKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEMDPSDIMGET
SDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEKP
ELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKPV
IDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIILND
PMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHSPALVLRAYS
KNNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDI
VFELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIK
DKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLITHFADSFIDS
LSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLLFRTGDLRQA
DLDKYDAMKILIRSLDYLNNDIFSLSRIKVGLDEFATIKKAHFSKMVSFE
GPPIKTGLLDLTELMKSQDLLNLNYDNIRNSNLISFSKLICCEGSDNIND
GLEFLSDDPMNFTEGEAIHSTPIFNIYYSKRGERHMTYRNAIKLLIERET
KIFEEAFTFSENGFISPENLGCLEAVVSLIKLLKTNEWSTVIDKCIHICL
IKNGMDHMYHSFDVPKCFINWVMFREFINSLPGTDIPPWNVMTENFKKKC
IALINSKF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oro Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Q291 R292 K302 H306 C419 G420 G422 K423 K439 P440 R592 A593 R595 R600 T642 K643 Y677 E758 H760 H761 V764 K768 L1113 Q1116 V1118 Y1120 D1123
Binding residue
(residue number reindexed from 1)		Q291 R292 K302 H306 C419 G420 G422 K423 K427 P428 R575 A576 R578 R583 T625 K626 Y660 E741 H743 H744 V747 K751 L1045 Q1048 V1050 Y1052 D1055
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7oro, PDBe:7oro, PDBj:7oro
PDBsum7oro
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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