Structure of PDB 7orm Chain A Binding Site BS01

Receptor Information
>7orm Chain A (length=2145) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQFM
INNDLIDKSEKLKLFKNFCGIGKHKQEVSKPKILDFDDANMYLASLTMME
QSKKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCIS
DFSTLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVY
SIIVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPG
LFLTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNS
LAISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDI
YLSDYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEK
HHVMVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLA
DTSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKENYEML
RNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVIEQIMDMMIDHKKFYFT
FFNKGQKTSKDREIFVGEYEAKMCMYAVERIAKERCKLNPDEMISEPGDG
KLKVLEQKSEQEIRFLVETTRQKNREIDEAIEIEKLSLGKAKGLKMEINA
DMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCNYMDKELILPDEL
LFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCA
MSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFA
MKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTS
VGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNM
LPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIK
LLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEM
DPSDIMGETSDMRGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVE
LFTYLLEKPELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIE
QILFSHKPVIDFSGIRDKYINLGKVTFTEAYRLLMRDLSSLELTNDDIQV
IYSYIILNDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHS
PALVLRAYSKNNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMN
EAEKGQRDIVFELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFC
SLMQGNLIKDKEWYTVHYLKQILSGGHKAIMQHNATSEQNIAFECFKLIT
HFADSFIDSLSRSAFLQLIIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLL
FRTGDLRQADLDKYDAMKSHERVTLTITGYNRSITIIGEDNKLTYAELCL
TRKTPENITISGRKLLGSRHGLKFENMSKIQNYYITYRKKDRHQFVYQIH
SHESITRRNEEHNEITPVCVVNVAEVDGDQRILIRSLDYLNNDIFSLSRI
KVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLNLNYDNI
RNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTPIFNIYY
SKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGCLEAVVS
LIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPKCFMGNPITRDIN
WVMFREFINSLPGTDIPPWNVMTENFKKKCIALINSKFSEFTKLM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7orm Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q291 R292 K302 H306 G420 I421 G422 Q426 P440 R592 A593 R595 R600 T642 K643 Y677 E758 H760 H761 V764 K768 L1113 Q1116 V1118 Y1120 D1123
Binding residue
(residue number reindexed from 1)		Q291 R292 K302 H306 G420 I421 G422 Q426 P431 R583 A584 R586 R591 T633 K634 Y668 E749 H751 H752 V755 K759 L1054 Q1057 V1059 Y1061 D1064
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7orm, PDBe:7orm, PDBj:7orm
PDBsum7orm
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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