Structure of PDB 7orl Chain A Binding Site BS01

Receptor Information
>7orl Chain A (length=2183) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKKKLEPKQINNALVLWEQQFMINNDLIDKSE
KLKLFKNFCGIGKHKQFKNKMLEDLEVSKPKILDFDDANMYLASLTMMEQ
SKKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISD
FSTLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVYS
IIVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGL
FLTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSL
AISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIY
LSDYDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKH
HVMVDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLAD
TSRHNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKELQKMRL
ANPMFVTDEQVCLEVGHCNYEMLRNAMPNYTDYISTKVFDRLYELLDKKV
LTDKPVIEQIMDMMIDHKKFYFTFFNKGQKTSKDREIFVGEYEAKMCMYA
VERIAKERCKLNPDEMISEPGDGKLKVLEQKSEQEIRFLVETTRQKNREI
DEAIEALALGKIEKLSLGKAKGLKMEINADMSKWSAQDVFYKYFWLIALD
PILYPQEKERILYFMCNYMDKELILPDELLFNLLDQKVAYQNDIIATMTN
QLNSNTVLIKRNWLQGNFNYTSSYVHSCAMSVYKEILKEAITLLDGSILV
NSLVHSDDNQTSITIVQDKMENDKIIDFAMKEFERACLTFGCQANMKKTY
VTNCIKEFVSLFNLYGEPFSIYGRFLLTSVGDCAYIGPYEDLASRISSAQ
TAIKHGCPPSLAWVSIAISHWMTSLTYNMLPGQSNDPIDYFPAENRKDIP
IELNGVLDAPLSMISTVGLESGNLYFLIKLLSKYTPVMQKRESVVNQIAE
VKNWKVEDLTDNEIFRLKILRYLVLDAEMDPSDIMGETSDMRGRSILTPR
KFTTAGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEKPELLVTKGEDMKD
YMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKPVIDFSGIRDKEKE
PDILGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIILNDPMMITIANT
HILSIYGSPQRRMGMSCSTMPEFRNLKLIHHSPALVLRAYSKNNPDIQGA
DPTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDIVFELKEMTR
FYQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIKDKEWYTVHY
LKQILSGGHKAIMQHNATSEQNIAFECFKLITHFADSFIDSLSRSAFLQL
IIDEFSYKDVKVSKLYDIIKNGYNRTDFIPLLFRTGDLRQADLDKYDAMK
SHERVTWNDWQTSRHLDMGSINLTITGYNRSITIIGEDNKLTYAELCLTR
KTPENITISGRKLLGSRHGLKFENMSKIQTYPGNYYITYRKKDRHQFVYQ
IHSHESITRRNEEHMAIIYNEITPVCVVNVAEVDGDQRILIRSLDYLNND
IFSLSRIKVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLL
NLNYDNIRNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHST
PIFNIYYSKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLG
CLEAVVSLIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPINWVMF
REFINSLPGTDIPPWNVMTENFKKKCIALINSK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7orl Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C20 V21 Y714 R820 N823 R824 R958 Q1145 D1187 V1239 T1258 R1614 H1620 H1621 A2013 H2014 K2017
Binding residue
(residue number reindexed from 1)		C20 V21 Y704 R810 N813 R814 R935 Q1115 D1157 V1209 T1228 R1574 H1580 H1581 A1970 H1971 K1974
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7orl, PDBe:7orl, PDBj:7orl
PDBsum7orl
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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