Structure of PDB 7orj Chain A Binding Site BS01

Receptor Information
>7orj Chain A (length=2129) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYQEYQQFLARINTARDACVAKDIDVDLLMARKDYFGRELCKSLNIEYR
NDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSNE
SSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELYP
TIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCPE
FWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKKD
YSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLHD
QKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGKM
MDIGDKAIEYEEFCMSLKSKALEPKQINNALVLWEQQFMINNDLIDKSEK
LKLFKNFCGIGKHVSKPKILDFDDANMYLASLTMMEQSKKILSKSNGLKP
DNFILNEFGSRIKDANKETYDNMHKIFETGYWQCISDFSTLMKNILSVSQ
YNRHNTFRIAMCANNNVFAIVFPSADIKTKKATVVYSIIVLHKEEENIFN
PGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGLFLTTCLLFKHDNP
TLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSLAISSNVKDYIAEK
FSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDIYLSDYDITQKGIKD
NRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVMVDLAKTILEI
ECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSRHNHLRNRIEN
RNNFRRSITTISTFTSSKSCLKIGDFRKEMLRNAMPNYTDYISTKVFDRL
YELLDKKVLTDKPVIEQIMDMMIDHKKFYFTFFNKGQKTSKDREIFVGEY
EAKMCMYAVERIAKERCKLNPDEMISEPGDGKLKVLEQKSEQEIRFLVET
TRQKNREIDEAIEALATLGKIEKLSLGKAKGLKMEINADMSKWSAQDVFY
KYFWLIALDPILYPQEKERILYFMCNYMDKELILPDELLFNLLDQKVAYQ
NDIIATMTNQLNSNTVLIKRNWLQGNFNYTSSYVHSCAMSVYKEILKEAI
TLLDGSILVNSLVHSDDNQTSITIVQDKMENDKIIDFAMKEFERACLTFG
CQANMKKTYVTNCIKEFVSLFNLYGEPFSIYGRFLLTSVGDCAYIGPYED
LASRISSAQTAIKHGCPPSLAWVSIAISHWMTSLTYNMLPGQSNDPIDYF
PAENRKDIPIELNGVLDAPLSMISTVGLESGNLYFLIKLLSKYTPVMQKR
ESVVNQIAEVKNWKVEDLTDNEIFRLKILRYLVLDAEMDPSDIMGETSDM
RGRSILTPRKFTTAGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEKPELL
VTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKPVIDF
SGIRDKKEPDILGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIILNDP
MMITIANTHILSIYGSPQRRMGMSCSTMPEFRNLKLIHHSPALVLRAYSK
NNPDIQGADPTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDIV
FELKEMTRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIKD
KEWYTVHYLKQILSSEQNIAFECFKLITHFADSFIDSLSRSAFLQLIIDE
FSYKDVKVSKLYDIIKNGYNRTDFIPLLFRTGDLRQADLDKYDAMKSHER
VTWNDWQTSRHLDMGSINLTITGYNRSITIIGEDNKLTYAELCLTRKTPE
NITISGRKLLGSRHGLKFENMSKIQTYPGNYYITYRKKDRHQFVYQIHSH
ESITRRNEEHMAIIYNEITPVCVVNVAEVDGDQRILIRSLDYLNNDIFSL
SRIKVGLDEFATIKKAHFSKMVSFEGPPIKTGLLDLTELMKSQDLLNLNY
DNIRNSNLISFSKLICCEGSDNINDGLEFLSDDPMNFTEGEAIHSTPIFN
IYYSKRGERHMTYRNAIKLLIERETKIFEEAFTFSENGFISPENLGCLEA
VVSLIKLLKTNEWSTVIDKCIHICLIKNGMDHMYHSFDVPINWVMFREFI
NSLPGTDIPPWNVMTENFKKKCIALINSK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7orj Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		Q291 K302 C419 H424 K439 P440 A548 R592 A593 R595 R600 T642 K643 Y677 K679 E758 H760 H761 K768 Q1116 V1118 Y1120 D1123 I1125
Binding residue
(residue number reindexed from 1)		Q291 K302 C408 H413 K416 P417 A525 R569 A570 R572 R577 T619 K620 Y654 K656 E735 H737 H738 K745 Q1045 V1047 Y1049 D1052 I1054
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7orj, PDBe:7orj, PDBj:7orj
PDBsum7orj
PubMed35173159
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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