Structure of PDB 7oqc Chain A Binding Site BS01

Receptor Information
>7oqc Chain A (length=132) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SALYFQNLPSRPANKENYTRLLLKHINPNNKYAINPSLPLPHNKLLLDDQ
MGLLEVSISRSSKMTNQAFLTFVTQEEADRFLEKYTTTALKVQGRKVRMG
KARTNSLLGLSIEMQKYNLDIKKVLKARKLKR
Ligand information
>7oqc Chain 1 (length=558) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auacuuaccuuaagauaucagaggagaguccuacugaucaaacaugcgcu
uccaauaguagaaggacguuaagcauuuaucauugaacuauaauuguuca
uugaagucauugaugcaaacuccuuggucacacacacauacggcgcggaa
ggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucc
cuugauuccuuuggggauuuuuggguuaaacugauuuuuggggcccuuug
uuucuucugccuggagaaguuugacaccaaauucaaauugguguuagggg
agcuggggccuuucaaaagagagcuuuguagaggcauucuuuuugacuac
uuuucucuagcgugccauuuuaguuuuugacggcagauucgaaugaacuu
aaguuuaugaugaagguauggcuguugagauuauuuggucgggauuguag
uuugaagaugugcucuuuugagcagucucaacuuugcucguucccguuau
gggaaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuu
ugauuuau
...........<<<<.<<<<<<<<<...>>>>.>>>>><<<<<<<<<.<<
<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<.......>>>>>
.>>>.......>>>>>.>>>>>>>>.....................>>>>
>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.<.<<
<..<<<<<<<..>>>>>>>...>>>.>.>>>>>>>..>>>>>>>((....
...<<<<<....))>>>>>...<<<<<<<<.......>>>>>>>>.>>>>
><<<<<<<<<<<<<<<<<..<<<<...<<.<<<<...<<<<<..<<<<<<
..<<<<.......<<<<...<<<<<<<.<<<<<<...<<<<.<<<<<<..
..>>>>>>..>>>>......>>>>>>>>>>>>>..>>>>.>>>>..>>>>
>>.>>>>>..<<<<<....>>>>>.>>>>.>>...>>>>.<<<<<<...>
>>>>>...>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>........
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oqc Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		Y5 Q7 R12 A14 N15 K16 N18 H43 E64 S66 I67 S68 R69 K72 F78 Q102 G103 R104 K105 R107 A111 N114 L116 D136 I137 K138 K139
Binding residue
(residue number reindexed from 1)		Y4 Q6 R11 A13 N14 K15 N17 H42 E55 S57 I58 S59 R60 K63 F69 Q93 G94 R95 K96 R98 A102 N105 L107 D120 I121 K122 K123
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oqc, PDBe:7oqc, PDBj:7oqc
PDBsum7oqc
PubMed34349264
UniProtP32605|RU1A_YEAST U1 small nuclear ribonucleoprotein A (Gene Name=MUD1)

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