Structure of PDB 7opk Chain A Binding Site BS01

Receptor Information
>7opk Chain A (length=649) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIPAAFRWLSNKYPKIISPVVEERPIVMPDGTEIPVDATRPNPNGEEFDN
LYLDMNGIVHPCSHPEDKPAPKDEEEMMIEIFKYTDRIVKMVRPRKILMI
AVDGVAPRAKMNQQRSRRFRAAQEAKEKEEEKKKAFDSNSITPGTPFMDI
LAASLRYWCAYKLNTDPAWAKLKVIISDATVPGEGEHKIMEFIRSQRSSP
EHNPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFFQEKPFIWLHVSI
LREYLAAELEVPNLPFRWDLERAIDDWVFLCFFVGNDFLPHLPALEIREN
GIDTLTAIWKDNLPIMGGYLTKDGHVDLERAQYILNGLAKQEDAIFRRRR
EVEERREAVDTVRLWEEGYADRYYEQKFKVDPKDIEFRHKVGRAYAEGLA
WVLQYYYQGCPSWEWFYPYHYAPFAADFVDLAKMEIKFEKGRISRPFEQL
MSVLPAASRHAIPEVYHDLMTDPNSPIIDFYPEEFEIDLNGKKMAWQGVA
LLPFIEMPRLLAAMKEREHLLSEEDRARNEPGFDVLLISDAHPGLYEDIT
SHFYSKKQGAPKFKLNPRRSDGLAGKVEKIEGYVPHGSLVYPLARNSMPD
VDYDRSITVRYIMPSSAHQHKSMLLRGVKLPPPALSRSDIEIIRSKAKN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7opk Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7opk Observation of conformational changes that underlie the catalytic cycle of Xrn2.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D104 E209 E211
Binding residue
(residue number reindexed from 1)		D103 E184 E186
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0004534 5'-3' RNA exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7opk, PDBe:7opk, PDBj:7opk
PDBsum7opk
PubMed36008487
UniProtG0S058

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