Structure of PDB 7ogj Chain A Binding Site BS01

Receptor Information
>7ogj Chain A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYPVKPEEMDWSELYPEFFAPQAQVEFADIGCGYGGLLVELSPLFPDTLI
LGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQ
LTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLEL
HDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFP
AIFRRIQDPV
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain7ogj Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ogj Crystal structure of human METTL1 in complex with SAH
Resolution1.59 Å
Binding residue
(original residue number in PDB)		G54 C55 G56 E77 I78 R79 S109 N110 A111 L130 F131 T208 E210
Binding residue
(residue number reindexed from 1)		G31 C32 G33 E54 I55 R56 S86 N87 A88 L107 F108 T185 E187
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.33: tRNA (guanine(46)-N(7))-methyltransferase.
Gene Ontology
Molecular Function
GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ogj, PDBe:7ogj, PDBj:7ogj
PDBsum7ogj
PubMed
UniProtQ9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Gene Name=METTL1)

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