Structure of PDB 7nz7 Chain A Binding Site BS01

Receptor Information

>7nz7 Chain A (length=166) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PDGPCVVSVQETEKWMEEAMRMAKEALENIEVPVGCLMVYNNEVVGKGRN
EVNQTKNATRHAEMVAIDQVLDWCHQHGQSPSTVFEHTVLYVTVEPCIMC
AAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRA
EEAVELLKTFYKQENP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7nz7 Chain A Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7nz7 The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.
Resolution	2.96 Å
Binding residue (original residue number in PDB)	H71 C107 C110
Binding residue (residue number reindexed from 1)	H61 C97 C100
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.4.33: tRNA(adenine(34)) deaminase.

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0008251	tRNA-specific adenosine deaminase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0052717	tRNA-specific adenosine-34 deaminase activity

	Biological Process
GO:0002100	tRNA wobble adenosine to inosine editing
GO:0008033	tRNA processing

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Molecular Function

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Biological Process

External links

PDB	RCSB:7nz7, PDBe:7nz7, PDBj:7nz7
PDBsum	7nz7
PubMed	34057470
UniProt	Q6P6J0\|ADAT2_MOUSE tRNA-specific adenosine deaminase 2 (Gene Name=Adat2)

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