Structure of PDB 7nus Chain A Binding Site BS01

Receptor Information
>7nus Chain A (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
Ligand information
>7nus Chain D (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FSDSSSVPNFFRNCg
Receptor-Ligand Complex Structure
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PDB7nus Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		K51 L54 L57 G58 I61 M62 Y67 Q72 V93 K94 H96 I99 Y100
Binding residue
(residue number reindexed from 1)		K26 L29 L32 G33 I36 M37 Y42 Q47 V68 K69 H71 I74 Y75
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7nus, PDBe:7nus, PDBj:7nus
PDBsum7nus
PubMed34977581
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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