Structure of PDB 7nga Chain A Binding Site BS01

Receptor Information
>7nga Chain A (length=650) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQAS
ESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVV
KSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVY
NNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEK
HILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIANPFKEKLLEIMA
SIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNE
ALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNLDETDEFLMNLFFDNKK
MLKKLAENPKEKLIKLRNTILEQFTRSESRGIIFTKTRQSTYALSQWIME
NAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATT
VAEEGLDIKECNIVIRYGLVTARADESTYVLVTREIVNDFREKMMYKAIN
RVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKN
CSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKNGEIICKCGQAWGT
MMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7nga MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		K451 E452 H578 Q581 T769 R843 H927 R985 K1002
Binding residue
(residue number reindexed from 1)		K146 E147 H268 Q271 T429 R484 H568 R615 K632
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0038187 pattern recognition receptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0002376 immune system process
GO:0009615 response to virus
GO:0016925 protein sumoylation
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0039530 MDA-5 signaling pathway
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0060337 type I interferon-mediated signaling pathway
GO:0060760 positive regulation of response to cytokine stimulus
GO:0071360 cellular response to exogenous dsRNA
GO:0098586 cellular response to virus
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nga, PDBe:7nga, PDBj:7nga
PDBsum7nga
PubMed34795277
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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