Structure of PDB 7nel Chain A Binding Site BS01
Receptor Information
>7nel Chain A (length=242) Species:
9606
(Homo sapiens) [
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SLALSLTADQIISALLEAEPPILYSEYDPSRPFSEAYMMGLLTNLADREL
VHMINWAKKVPGFVDLSLHDQVHLLESAWLEILMIGLVWRSMDHPGKLLF
APDLLLDREQGKSVEGMVEIFDMLLATSERFREMKLQREEFVCLKAIILL
NSGVYTFSTLKSLENKEKIHRMLDKITDALIWYMAKSGLSLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKSKNVVPLSDLLLEMLDAHR
Ligand information
>7nel Chain C (length=12) Species:
9606
(Homo sapiens) [
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HKILHRLLQDSS
Receptor-Ligand Complex Structure
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PDB
7nel
A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.
Resolution
1.45 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 V376 E380 D538 L539 E542
Binding residue
(residue number reindexed from 1)
I54 K58 L68 V72 E76 D232 L233 E236
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:7nel
,
PDBe:7nel
,
PDBj:7nel
PDBsum
7nel
PubMed
34006920
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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