Structure of PDB 7ne6 Chain A Binding Site BS01

Receptor Information
>7ne6 Chain A (length=418) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKE
GKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGI
PLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGASFS
FGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLMAPT
YKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLH
NMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQE
EKKRSGAIQVLSSFRRKVRMLAEPVKTCRGSDEVWSDSEQSFLDPDIGGV
AVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKH
GLALWEAKMAEKAREKEE
Ligand information
Receptor-Ligand Complex Structure
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PDB7ne6 Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		R1261 R1262 S1286 S1290 M1293 Y1294 K1299 R1302 S1303 D1384 H1386 N1387 Y1902 H1904
Binding residue
(residue number reindexed from 1)		R125 R126 S150 S154 M157 Y158 K163 R166 S167 D248 H250 N251 Y390 H392
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7ne6, PDBe:7ne6, PDBj:7ne6
PDBsum7ne6
PubMed36070377
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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