Structure of PDB 7n6w Chain A Binding Site BS01

Receptor Information
>7n6w Chain A (length=591) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNP
QEVVLENVTEHFNMWKNNMVEQMQEDIISLWDQSLKPCVKLTPLCVTLNC
KDVNAERGEIKNCSFNITTSIRDEVQKEYALFYKLDVVPIDNNNTSYRLI
SCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVST
VQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEI
NCTRPNNNTRKSIHIGPGRAFYTTGEIIGDIRQAHCNISRAKWNDTLKQI
VIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWN
NNNTITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGG
INENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRAVFLGF
LGAAGSTMGAASMTLTVQARLLLSGIVQQQNNLLRAIEAQQRMLQLTVWG
IKQLQARVLAVERYLGDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRI
WNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLEL
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain7n6w Chain G Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7n6w Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer.
Resolution4.7 Å
Binding residue
(original residue number in PDB)		S209 E211
Binding residue
(residue number reindexed from 1)		S165 E167
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006915 apoptotic process
GO:0019049 virus-mediated perturbation of host defense response
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019082 viral protein processing
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0075512 clathrin-dependent endocytosis of virus by host cell
GO:1903905 positive regulation of establishment of T cell polarity
GO:1903908 positive regulation of plasma membrane raft polarization
GO:1903911 positive regulation of receptor clustering
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n6w, PDBe:7n6w, PDBj:7n6w
PDBsum7n6w
PubMed34549974
UniProtQ75760

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