Structure of PDB 7mx1 Chain A Binding Site BS01
Receptor Information
>7mx1 Chain A (length=220) Species:
9606
(Homo sapiens) [
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CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPREGDARLPYLRTWFRTRSAIIL
HLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCC
KELASRLRYARTMVDKLLSS
Ligand information
>7mx1 Chain C (length=5) Species:
9606
(Homo sapiens) [
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PLAST
Receptor-Ligand Complex Structure
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PDB
7mx1
Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles.
Resolution
1.64 Å
Binding residue
(original residue number in PDB)
K413 W414 V415 D416 Y417 L491 R516 H538 K540
Binding residue
(residue number reindexed from 1)
K42 W43 V44 D45 Y46 L120 R143 H165 K167
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:7mx1
,
PDBe:7mx1
,
PDBj:7mx1
PDBsum
7mx1
PubMed
34346472
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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