Structure of PDB 7mts Chain A Binding Site BS01

Receptor Information
>7mts Chain A (length=783) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRI
NRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASTAITGVIGGSYSD
VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMA
EILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMS
RAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDG
WGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFR
EFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMH
RALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRF
GDGIGRYNIFTYLRAGGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPA
SRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPN
ASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPV
VKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCY
SALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAW
LVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAF
KTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVS
VSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRA
Ligand information
Ligand IDZQY
InChIInChI=1S/C20H23N7O2S/c1-3-4-15-11-16-18(22-20(28-2)23-19(16)30-15)21-10-9-13-5-7-14(8-6-13)29-12-17-24-26-27-25-17/h5-8,11H,3-4,9-10,12H2,1-2H3,(H,21,22,23)(H,24,25,26,27)
InChIKeyACCUSJFCOLLWHH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CCCc1cc2c(nc(nc2s1)OC)NCCc3ccc(cc3)OCc4[nH]nnn4
CACTVS 3.385CCCc1sc2nc(OC)nc(NCCc3ccc(OCc4[nH]nnn4)cc3)c2c1
ACDLabs 12.01COc1nc(NCCc2ccc(OCc3nnn[NH]3)cc2)c2cc(CCC)sc2n1
FormulaC20 H23 N7 O2 S
Name2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine
ChEMBL
DrugBank
ZINC
PDB chain7mts Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mts G-protein activation by a metabotropic glutamate receptor.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G640 F643 R724 M728 S731 N735 M794
Binding residue
(residue number reindexed from 1)		G593 F596 R677 M681 S684 N688 M747
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mts, PDBe:7mts, PDBj:7mts
PDBsum7mts
PubMed34194039
UniProtQ14416|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

[Back to BioLiP]