Structure of PDB 7mop Chain A Binding Site BS01

Receptor Information
>7mop Chain A (length=2445) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADCRALIDKLKDEQLLLELQWVDLLDRFDGILADAGQQLKMLLLAVLNFT
ALLIEYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRT
PLLTRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYIHIE
QLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAV
QARLHAISILVYSSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIV
HKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFL
YHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLIT
NLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIQCIPQRAALLKSMLN
FLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVT
VFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCL
NARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAV
DELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKIPIPLMDYILNV
MKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQA
VAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRE
LACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVN
QWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQK
LVAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGPAARSTASALTK
LLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKF
LCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVE
KMVNPTTVLESPHSLPAKQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYG
GRMAESMLAILCHILRGEPVIRERLSKEEEEAKCLEKFQDADPLEQDELH
TFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQ
VWEAADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLF
EELKLPCAWVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVL
LLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWFDDRSGRWCSYSASNNST
IDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLILIQ
GLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAEL
KSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATS
GAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALP
APRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYD
MLNALASKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKED
CSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNE
VKAALGRALAMAESTEKHARLQAVMCIISTIMENNIIRLFLKKGLVNDLA
RVPHSLDLSSPNMANTVNAALKPLETLSRIVNQNIPTTHPLMVRLSSIPT
ALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQ
LLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLS
ILQRSSSWLSVSMDAALGCRTNIFQIQTVHIHPQAAPVVCRHVLDTLIQL
AKVDFWDLLVKLDNMEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLIS
IGLTENQLQLSVEVLTSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGA
RHLGYTLCKQIGTLLAELREYNLEELQLPSMSMLTSKTSTQKFFLRVLQV
IIQLRDLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATEQ
KFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRL
RKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLL
REWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR
IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE
NDVSTLGYDLTFSTEVQEFGVCEVRDLKVTEENKKEYVHLVCQMRMTGAI
RKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH
KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNG
IQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mop Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Y941 V945 S948 T949 G1060 R1061 T1129 G1136 F1137 E1197
Binding residue
(residue number reindexed from 1)		Y768 V772 S775 T776 G822 R823 T872 G879 F880 E940
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0061630 ubiquitin protein ligase activity
GO:0140852 histone ubiquitin ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006338 chromatin remodeling
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0007030 Golgi organization
GO:0010637 negative regulation of mitochondrial fusion
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0031398 positive regulation of protein ubiquitination
GO:0032922 circadian regulation of gene expression
GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0048511 rhythmic process
GO:0061025 membrane fusion
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mop, PDBe:7mop, PDBj:7mop
PDBsum7mop
PubMed34314700
UniProtQ7Z6Z7|HUWE1_HUMAN E3 ubiquitin-protein ligase HUWE1 (Gene Name=HUWE1)

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