Structure of PDB 7mjz Chain A Binding Site BS01

Receptor Information
>7mjz Chain A (length=444) Species: 820 (Bacteroides uniformis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADDNKKLFIETYGCQMNVADSEVIASVMQMAGYSVADTLEEADAVFMNTC
SIRDNAEQKILNRLEFFHSLKKKKRGLIVGVLGCMAERVKDDLITNHHVD
LVVGPDAYLTLPELIASVEAGEKAMNVELSTTETYRDVIPSRICGNHISG
FVSIMRGCNNFCTYCIVPYTRGRERSRDVESILNEVADLVAKGYKEVTLL
GQNVNSYRFEKPDGETITFPMLLRTVAEAAPGVRIRFTTSHPKDMSDETL
QVIADMPNVCKHIHLPVQSGSSRILKLMNRKYDREWYMDRVAAIRRIIPD
CGLSTDIFSGFHSETEEDHQLSLSLMEECGYDSAFMFKYSERPGTHASKY
LPDDVPEEVKIRRLNEIIALQNRLSAEANARCVGKTYEVLVEGVSKRSRD
QLFGRTEQNRVVVFDRGTHRVGDFVMVKVTESSSATLKGEEVAG
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7mjz Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mjz Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB.
Resolution2.08 Å
Binding residue
(original residue number in PDB)		G26 C27 N30 C63 S64 I65 C97 V180
Binding residue
(residue number reindexed from 1)		G13 C14 N17 C50 S51 I52 C84 V167
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.4.3: tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0035596 methylthiotransferase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0035600 tRNA methylthiolation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mjz, PDBe:7mjz, PDBj:7mjz
PDBsum7mjz
PubMed34526715
UniProtA0A174GYG1

[Back to BioLiP]