Structure of PDB 7mix Chain A Binding Site BS01

Receptor Information
>7mix Chain A (length=1326) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEP
YFIGIFCFEAGIKIIALGFVSYLRNGWNVMDFVVVLTGILATAGTDFDLR
TLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAI
IGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPG
PNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPL
IIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYL
EWIFKAEEVMLAEEDRNFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNT
LCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSF
NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLR
NLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNF
DTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFG
NYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSP
MSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALRRFCHYIVT
MRYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEM
VIKMIDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKT
IKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC
TDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTV
STGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIF
VALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQ
YKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFT
SMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNF
INLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFF
IYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIM
LSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF
EYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLG
LGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAG
TKQHQCDAELRKEISVVWANLPQKTL
Ligand information
>7mix Chain B (length=25) Species: 6492 (Conus magus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CKGKGAKCSRLMYDCCTGSCRSGKC
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mix Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T641 P642 T643 T644 D664 Y1310 D1345 P1368 M1369 K1372 D1628 D1629 E1659
Binding residue
(residue number reindexed from 1)		T495 P496 T497 T498 D518 Y799 D834 P857 M858 K861 D1117 D1118 E1148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008331 high voltage-gated calcium channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007268 chemical synaptic transmission
GO:0050804 modulation of chemical synaptic transmission
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098703 calcium ion import across plasma membrane
GO:1904645 response to amyloid-beta
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0043025 neuronal cell body
GO:0045202 synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mix, PDBe:7mix, PDBj:7mix
PDBsum7mix
PubMed34234349
UniProtQ00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (Gene Name=CACNA1B)

[Back to BioLiP]