Structure of PDB 7mgw Chain A Binding Site BS01

Receptor Information
>7mgw Chain A (length=537) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFG
GIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNT
IMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPA
EEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSG
KVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWID
AAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV
IFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFF
LMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSL
VTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEM
LGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILG
YCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPE
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain7mgw Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mgw Illumination of serotonin transporter mechanism and role of the allosteric site.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		F105 Y121 S372
Binding residue
(residue number reindexed from 1)		F27 Y43 S294
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7mgw, PDBe:7mgw, PDBj:7mgw
PDBsum7mgw
PubMed34851672
UniProtP31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)

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