Structure of PDB 7md4 Chain A Binding Site BS01

Receptor Information
>7md4 Chain A (length=724) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIM
ITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGL
YNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLCKSHGCTAE
GLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCV
NFSFCQDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCEKTIDS
VTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRS
YALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQ
GKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELL
KFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDIDPPL
RSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYV
QTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAED
SELFELDYCLKGLKLPSREEHRPFEKVVNKESLVISGLRHFTGYRIELQA
CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEP
KEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYL
Ligand information
>7md4 Chain N (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KELEESSFRKTFEDYLHNVVFV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7md4 Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		F88 F89 R118 Y144
Binding residue
(residue number reindexed from 1)		F82 F83 R112 Y138
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7md4, PDBe:7md4, PDBj:7md4
PDBsum7md4
PubMed35177603
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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