Structure of PDB 7mbm Chain A Binding Site BS01

Receptor Information
>7mbm Chain A (length=339) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAK
IISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPI
LKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFD
RRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKG
SCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFS
GDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPII
ASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERE
Ligand information
>7mbm Chain P (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcgagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatccga
Receptor-Ligand Complex Structure
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PDB7mbm Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
ResolutionN/A
Binding residue
(original residue number in PDB)		R220 R251
Binding residue
(residue number reindexed from 1)		R210 R241
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0006325 chromatin organization
GO:0006974 DNA damage response
GO:0043627 response to estrogen
GO:0045815 transcription initiation-coupled chromatin remodeling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0035097 histone methyltransferase complex
GO:0044665 MLL1/2 complex
GO:0044666 MLL3/4 complex
GO:0048188 Set1C/COMPASS complex
GO:0071339 MLL1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mbm, PDBe:7mbm, PDBj:7mbm
PDBsum7mbm
PubMed34928138
UniProtQ15291|RBBP5_HUMAN Retinoblastoma-binding protein 5 (Gene Name=RBBP5)

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