Structure of PDB 7m85 Chain A Binding Site BS01

Receptor Information
>7m85 Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERAAIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB7m85 Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 R61 S62 K86 L89 R93 K311 R313 P316 K317 T318 G320 C321 S322 K323 N324 P326
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 R64 S65 K89 L92 R96 K309 R311 P314 K315 T316 G318 C319 S320 K321 N322 P324
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7m85, PDBe:7m85, PDBj:7m85
PDBsum7m85
PubMed34088846
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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