Structure of PDB 7m43 Chain A Binding Site BS01

Receptor Information
>7m43 Chain A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEAC
SIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQ
MWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQ
KAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDS
LRQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLY
FTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPT
EKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB7m43 Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints.
Resolution1.978 Å
Binding residue
(original residue number in PDB)		W274 V462 K463 G464 K472 R514 R517 K521 L527 S528 E529 H530 H541
Binding residue
(residue number reindexed from 1)		W24 V212 K213 G214 K217 R259 R262 K266 L272 S273 E274 H275 H286
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:7m43, PDBe:7m43, PDBj:7m43
PDBsum7m43
PubMed35680862
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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